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ea0013p3 | Bone | SFEBES2007

Differences in parathyroid hormone secretory rhythm and sensitivity in aging women with osteoporosis and declining insulin like growth factor-1 concentration, compared to young healthy premenopausal women

Joseph Franklin , Ahmad Aftab M , Joshi Ashwin , Wakil Amar , Durham Brian H , Whittingham Pauline , Fraser William D , Vora Jiten P

Introduction: Adult growth hormone deficiency (AGHD) is associated with target organ insensitivity to parathyroid hormone (PTH) and abnormal PTH circadian rhythm. In aging women with established osteoporosis, GH and insulin like growth factor -1 (IGF-1) concentrations are low and administration of GH has been shown to increase bone turnover and bone mineral density (BMD), but the mechanisms remain unclear. Consequently we investigated the effects of declining GH and IGF-1 conc...

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Endocrine Abstracts

Differences in parathyroid hormone secretory rhythm and sensitivity in aging women with osteoporosis and declining insulin like growth factor-1 concentration, compared to young healthy premenopausal women

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